EZH2 ELISA Kit for Human(Homo sapiens) | EIAab.comEZH2 ELISA Kit for Human(Homo sapiens)

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EZH2 (Gene name),

Histone-lysine N-methyltransferase EZH2 (Protein name ), EZH2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

EZH2(KMT6);

Protein name:

Histone-lysine N-methyltransferase EZH2;

Alternative:

Enhancer of zeste homolog 2;ENX-1;Lysine N-methyltransferase 6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds ATRX via the SET domain (Probable). Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC1 and HDAC2. Interacts with PRAME.

Function:

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

746

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

746:

MVNGDHRIGI | FAKRAIQTGE | ELFFDYRYSQ | ADALKYVGIE | REMEIP

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

SMR:

Q15910

Pfam:

PF11616

STRING:

9606.ENSP00000320147

String:

Q15910

UniGene:

Hs.444082

KEGG:

hsa:2146

MIM:

601573

MIM:

277590

Uniprot:

Q15910

FOR

ELISA Kit for Human Histone-lysine N-methyltransferase EZH2

Cat.:

E7688h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Histone-lysine N-methyltransferase EZH2

Cat.:

E7688m

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MSDS:

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Packing:

96T

CLIA Kit for Human Histone-lysine N-methyltransferase EZH2

Cat.:

U7688m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Histone-lysine N-methyltransferase EZH2

Cat.:

U7688h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human Histone-lysine N-methyltransferase EZH2

Cat.:

P7688Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Histone-lysine N-methyltransferase EZH2

Cat.:

P7688Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Histone-lysine N-methyltransferase EZH2

Protein for Human Histone-lysine N-methyltransferase EZH2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2."
Chen H. , Rossier C. , Antonarakis S.E.
Genomics38:30-37(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres."
Laible G. , Wolf A. , Dorn R. , Reuter G. , Nislow C. , Lebersorger A. , Popkin D. , Pillus L. , Jenuwein T.
EMBO J.16:3219-3232(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5)
tissue: Brain.
tissue: Testis.
4.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Pancreas.
7.

"Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression."
Hobert O. , Jallal B. , Ullrich A.
Mol. Cell. Biol.16:3066-3073(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-746
8.

"Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein."
Cardoso C. , Timsit S. , Villard L. , Khrestchatisky M. , Fontes M. , Colleaux L.
Hum. Mol. Genet.7:679-684(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATRX
9.

"Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes."
Sewalt R.G.A.B. , van der Vlag J. , Gunster M.J. , Hamer K.M. , den Blaauwen J.L. , Satijn D.P.E. , Hendrix T. , van Driel R. , Otte A.P.
Mol. Cell. Biol.18:3586-3595(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EED;SUBCELLULAR LOCATION
10.

"Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation."
van der Vlag J. , Otte A.P.
Nat. Genet.23:474-478(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EED; HDAC1 AND HDAC2
11.

"The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos."
Satijn D.P.E. , Hamer K.M. , den Blaauwen J. , Otte A.P.
Mol. Cell. Biol.21:1360-1369(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EED
12.

"Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein."
Kuzmichev A. , Nishioka K. , Erdjument-Bromage H. , Tempst P. , Reinberg D.
Genes Dev.16:2893-2905(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE PRC2 COMPLEX WITH EED; RBBP4; RBBP7 AND SUZ12;METHYLTRANSFERASE ACTIVITY OF THE PRC2 COMPLEX;MUTAGENESIS OF CYS-588 AND HIS-689
13.

"Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins."
Sewalt R.G.A.B. , Lachner M. , Vargas M. , Hamer K.M. , den Blaauwen J.L. , Hendrix T. , Melcher M. , Schweizer D. , Jenuwein T. , Otte A.P.
Mol. Cell. Biol.22:5539-5553(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
14.

"Role of histone H3 lysine 27 methylation in Polycomb-group silencing."
Cao R. , Wang L. , Wang H. , Xia L. , Erdjument-Bromage H. , Tempst P. , Jones R.S. , Zhang Y.
Science298:1039-1043(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE PRC2 COMPLEX WITH EED; RBBP4; RBBP7 AND SUZ12;METHYLTRANSFERASE ACTIVITY OF THE PRC2 COMPLEX
15.

"EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer."
Bracken A.P. , Pasini D. , Capra M. , Prosperini E. , Colli E. , Helin K.
EMBO J.22:5323-5335(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;INDUCTION;TISSUE SPECIFICITY
16.

"Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity."
Pasini D. , Bracken A.P. , Jensen M.R. , Lazzerini Denchi E. , Helin K.
EMBO J.23:4061-4071(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EED AND SUZ12;METHYLTRANSFERASE ACTIVITY OF THE PRC2 COMPLEX
17.

"Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27."
Kirmizis A. , Bartley S.M. , Kuzmichev A. , Margueron R. , Reinberg D. , Green R. , Farnham P.J.
Genes Dev.18:1592-1605(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
18.

"Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3."
Kuzmichev A. , Jenuwein T. , Tempst P. , Reinberg D.
Mol. Cell14:183-193(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE PRC2 AND PRC3 COMPLEXES INCLUDING EED; EZH2; RBBP4; RBBP7 AND SUZ12;METHYLTRANSFERASE ACTIVITY OF THE PRC2 AND PRC3 COMPLEXES
19.

"SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex."
Cao R. , Zhang Y.
Mol. Cell15:57-67(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF THE PRC2 COMPLEX INCLUDING AEBP2; EED; EZH2; RBBP4 AND SUZ12;METHYLTRANSFERASE ACTIVITY OF THE PRC2 COMPLEX
20.

"Activated p53 suppresses the histone methyltransferase EZH2 gene."
Tang X. , Milyavsky M. , Shats I. , Erez N. , Goldfinger N. , Rotter V.
Oncogene23:5759-5769(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;INDUCTION
21.

"The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling."
Epping M.T. , Wang L. , Edel M.J. , Carlee L. , Hernandez M. , Bernards R.
Cell122:835-847(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RETINOIC ACID SIGNALING;INTERACTION WITH PRAME
22.

"Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation."
Kuzmichev A. , Margueron R. , Vaquero A. , Preissner T.S. , Scher M. , Kirmizis A. , Ouyang X. , Brockdorff N. , Abate-Shen C. , Farnham P.J. , Reinberg D.
Proc. Natl. Acad. Sci. U.S.A.102:1859-1864(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE PRC4 COMPLEX INCLUDING EED; EZH2; RBBP4; RBBP7; SUZ12 AND SIRT1;METHYLTRANSFERASE ACTIVITY OF THE PRC4 COMPLEX
23.

"Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3."
Cha T.-L. , Zhou B.P. , Xia W. , Wu Y. , Yang C.-C. , Chen C.-T. , Ping B. , Otte A.P. , Hung M.-C.
Science310:306-310(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EED AND SUZ12;PHOSPHORYLATION AT SER-21 BY AKT1;MUTAGENESIS OF SER-21
24.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-487;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
25.

"Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions."
Bracken A.P. , Dietrich N. , Pasini D. , Hansen K.H. , Helin K.
Genes Dev.20:1123-1136(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
26.

"Substrate preferences of the EZH2 histone methyltransferase complex."
Martin C. , Cao R. , Zhang Y.
J. Biol. Chem.281:8365-8370(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLTRANSFERASE ACTIVITY OF THE PRC2 COMPLEX
27.

"The polycomb group protein EZH2 is required for mammalian circadian clock function."
Etchegaray J.P. , Yang X. , DeBruyne J.P. , Peters A.H. , Weaver D.R. , Jenuwein T. , Reppert S.M.
J. Biol. Chem.281:21209-21215(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
28.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-487;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
29.

"The Polycomb group protein EZH2 directly controls DNA methylation."
Vire E. , Brenner C. , Deplus R. , Blanchon L. , Fraga M. , Didelot C. , Morey L. , Van Eynde A. , Bernard D. , Vanderwinden J.-M. , Bollen M. , Esteller M. , Di Croce L. , de Launoit Y. , Fuks F.
Nature439:871-874(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION OF THE PRC2 COMPLEX WITH DNMT1; DNMT3A AND DNMT3B
30.

Vire E. , Brenner C. , Deplus R. , Blanchon L. , Fraga M. , Didelot C. , Morey L. , Van Eynde A. , Bernard D. , Vanderwinden J.-M. , Bollen M. , Esteller M. , Di Croce L. , de Launoit Y. , Fuks F.
Nature446:824-824(2006)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
31.

"Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells."
Kim D.H. , Villeneuve L.M. , Morris K.V. , Rossi J.J.
Nat. Struct. Mol. Biol.13:793-797(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
32.

"pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene."
Kotake Y. , Cao R. , Viatour P. , Sage J. , Zhang Y. , Xiong Y.
Genes Dev.21:49-54(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
33.

"The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells."
Bracken A.P. , Kleine-Kohlbrecher D. , Dietrich N. , Pasini D. , Gargiulo G. , Beekman C. , Theilgaard-Moench K. , Minucci S. , Porse B.T. , Marine J.-C. , Hansen K.H. , Helin K.
Genes Dev.21:525-530(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE;INDUCTION
34.

"Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer."
Schlesinger Y. , Straussman R. , Keshet I. , Farkash S. , Hecht M. , Zimmerman J. , Eden E. , Yakhini Z. , Ben-Shushan E. , Reubinoff B.E. , Bergman Y. , Simon I. , Cedar H.
Nat. Genet.39:232-236(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DE NOVO DNA METHYLATION OF PRC2 TARGET GENES
35.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-487;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
36.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-487;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
37.

"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms."
Margueron R. , Li G. , Sarma K. , Blais A. , Zavadil J. , Woodcock C.L. , Dynlacht B.D. , Reinberg D.
Mol. Cell32:503-518(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE PRC2/EED-EZH1 COMPLEX
38.

"Role of hPHF1 in H3K27 methylation and Hox gene silencing."
Cao R. , Wang H. , He J. , Erdjument-Bromage H. , Tempst P. , Zhang Y.
Mol. Cell. Biol.28:1862-1872(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE PRC2 COMPLEX;METHYLTRANSFERASE ACTIVITY OF THE PRC2 COMPLEX
39.

"Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo."
Sarma K. , Margueron R. , Ivanov A. , Pirrotta V. , Reinberg D.
Mol. Cell. Biol.28:2718-2731(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EED; SUZ12 AND PHF1;METHYLTRANSFERASE ACTIVITY OF THE PRC2 COMPLEX;MUTAGENESIS OF HIS-689
40.

"The polycomb repressive complex 2 is a potential target of SUMO modifications."
Riising E.M. , Boggio R. , Chiocca S. , Helin K. , Pasini D.
PLoS ONE3:E2704-E2704(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION
41.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366; THR-367 AND THR-487;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
42.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
43.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-487;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
44.

"Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2."
Chen S. , Bohrer L.R. , Rai A.N. , Pan Y. , Gan L. , Zhou X. , Bagchi A. , Simon J.A. , Huang H.
Nat. Cell Biol.12:1108-1114(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-345 BY CDK1 AND CDK2;MUTAGENESIS OF THR-345
45.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-487;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
46.

"Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27."
Zhang Y. , Yang X. , Gui B. , Xie G. , Zhang D. , Shang Y. , Liang J.
J. Biol. Chem.286:42414-42425(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDYL
47.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-487;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
48.

"EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex."
Lee J.M. , Lee J.S. , Kim H. , Kim K. , Park H. , Kim J.Y. , Lee S.H. , Kim I.S. , Kim J. , Lee M. , Chung C.H. , Seo S.B. , Yoon J.B. , Ko E. , Noh D.Y. , Kim K.I. , Kim K.K. , Baek S.H.
Mol. Cell48:572-586(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
49.

"O-GlcNAcylation regulates EZH2 protein stability and function."
Chu C.S. , Lo P.W. , Yeh Y.H. , Hsu P.H. , Peng S.H. , Teng Y.C. , Kang M.L. , Wong C.H. , Juan L.J.
Proc. Natl. Acad. Sci. U.S.A.111:1355-1360(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-75;MUTAGENESIS OF SER-75;FUNCTION
50.

"Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin."
Morin R.D. , Johnson N.A. , Severson T.M. , Mungall A.J. , An J. , Goya R. , Paul J.E. , Boyle M. , Woolcock B.W. , Kuchenbauer F. , Yap D. , Humphries R.K. , Griffith O.L. , Shah S. , Zhu H. , Kimbara M. , Shashkin P. , Charlot J.F. , more...
Nat. Genet.42:181-185(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHE-641; SER-641; ASN-641; HIS-641 AND CYS-641
51.

"Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A."
Jankowska A.M. , Makishima H. , Tiu R.V. , Szpurka H. , Huang Y. , Traina F. , Visconte V. , Sugimoto Y. , Prince C. , O'Keefe C. , Hsi E.D. , List A. , Sekeres M.A. , Rao A. , McDevitt M.A. , Maciejewski J.P.
Blood118:3932-3941(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-685
52.

"Mutations in EZH2 cause Weaver syndrome."
Gibson W.T. , Hood R.L. , Zhan S.H. , Bulman D.E. , Fejes A.P. , Moore R. , Mungall A.J. , Eydoux P. , Babul-Hirji R. , An J. , Marra M.A. , Chitayat D. , Boycott K.M. , Weaver D.D. , Jones S.J.
Am. J. Hum. Genet.90:110-118(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS WVS SER-132; TYR-153 DEL AND TYR-689

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